Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort
A multi-omics analysis combined with artificial intelligence was conducted on a cohort of young patients (younger than 50 years) without major comorbidities including 47 “critical” (in the ICU under mechanical ventilation), 25 “non-critical” (in a non-critical care...
Optimized Sample Preparation and Data Processing of Data-Independent Acquisition Methods for the Robust Quantification of Trace-Level Host Cell Protein Impurities in Antibody Drug Products
Host cell proteins (HCPs) are a major class of bioprocess-related impurities generated by the host organism and are generally present at low levels in purified biopharmaceutical products. The monitoring of these impurities is identified as an important critical...
The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity
The small nucleolar particles of the C/D box snoRNP family participate in the biogenesis of ribosomes whose function is to decode the information carried by mRNA to synthesize proteins. Teams from the IMoPA (Nancy), IPHC/LSMBO/ProFI-Strasbourg (Strasbourg), GIM...
The Human Proteome Project reports 90% completion of the human proteome
Along with the publication of the “Blueprint” map of the Human Proteome in Nature Communications, JPR has just published a “virtual issue” of a selection of 60 publications on the human proteome celebrating 10 years of the Human Proteome...
