The “Proteomics and Mass Spectrometry of Biomolecules” research group (PMSB) is one of the 17 teams of the Institute of Pharmacology and Structural Biology (IPBS) in Toulouse, which is a mixed CNRS/Paul Sabatier University research unit. It is part of the Structural Biology and Biophysics department of the Institute. The team’s objective is to develop innovative proteomics strategies to gain new insights into protein function, regulation and dynamic interactions to solve fundamental biological questions. It is composed of 20 highly qualified people with complementary skills in mass spectrometry, biochemistry and bioinformatics. Research projects benefit from state-of-the-art instrumentation in a context of quality assurance certification (ISO 9001 since 2006 and NF X 50-900 since 2014).
Major research projects are devoted to the understanding of biological processes involved mainly in cancer and inflammation using mass spectrometry and proteomics. These projects also include methodological developments in proteomic strategies, like the identification of low-abundance proteins, quantitative proteomics, the characterization of post-translational modifications, and the analysis of protein complexes. Overall, the work of the team led to the publication of more than 80 articles since 2001 in high impact journals.