ProFI Proteomics
The Proteomics French Infrastructure is a national project set up to provide a unified service platform in proteomics studies.
It's open to both public and private collaborations.
Proteomics Services
Large scale protein identification and quantification
Current proteomics methods and instrumentation represent today a powerful tool to get new insights into complex biological systems.
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Targeted quantification
Targeted strategies have emerged ten years ago and are best suited when precise, ideally absolute, quantification of finite sets of proteins are required with highest sensitivity.
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Post-translational modifications: detection and quantification
Proteins are very often the subject of various post-translational modifications (PTMs) that can impact their association with other proteins and globally other biomolecules, their subcellular localization and their stability.
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Interactomics and protein complexes
Interactomics and protein complexes investigations are also based on our strategies and instrumentation for large-scale and targeted quantification.
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Characterization of intact proteins and complexes
The next frontiers in proteome research are the study of protein-ligand interactions, protein-peptide and protein-protein complexes, together with entire protein interaction networks by high-throughput methods.
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ProFI Proteomics Skills
Publications
On the international stage
National Networks
Tools and methods for the community
Last News
Optimized Sample Preparation and Data Processing of Data-Independent Acquisition Methods for the Robust Quantification of Trace-Level Host Cell Protein Impurities in Antibody Drug Products
Host cell proteins (HCPs) are a major class of bioprocess-related impurities generated by the host organism and are generally present at low levels in purified biopharmaceutical products. The monitoring of these impurities is identified as an important critical...
ProlineSuite Version 2.1.2 : New FDR Control Procedure
This new version is an intermediate release which fixes some bugs and improves some features : see Release Note to get the full list of changes. The main new feature is the validation process. A method based on the Benjamini-Hochberg procedure to control the FDR is...
The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity
The small nucleolar particles of the C/D box snoRNP family participate in the biogenesis of ribosomes whose function is to decode the information carried by mRNA to synthesize proteins. Teams from the IMoPA (Nancy), IPHC/LSMBO/ProFI-Strasbourg (Strasbourg), GIM...
