Publications

981 Entrées « ‹ 16 de 20 › »

2016

Plumel, M; Benhaim-Delarbre, M; Rompais, M; Thiersé, D; Sorci, G; Dorsselaer, A; Criscuolo, F; Bertile, F

Differential proteomics reveals age-dependent liver oxidative costs of innate immune activation in mice. Article de journal

Dans: J Proteomics., no. 135, p. 181-90., 2016.

BibTeX

Bragantini, B.; Tiotiu, D.; Rothe, B.; Saliou, J. M.; Marty, H.; Cianferani, S.; Charpentier, B.; Quinternet, M.; Manival, X.

Functional and Structural Insights of the Zinc-Finger HIT protein family members Involved in Box C/D snoRNP Biogenesis Article de journal

Dans: J Mol Biol, vol. 428, no. 11, p. 2488-2506, 2016, ISSN: 1089-8638 (Electronic) 0022-2836 (Linking), (Bragantini, Benoit Tiotiu, Decebal Rothe, Benjamin Saliou, Jean-Michel Marty, Helene Cianferani, Sarah Charpentier, Bruno Quinternet, Marc Manival, Xavier eng Research Support, Non-U.S. Gov’t Netherlands 2016/05/04 06:00 J Mol Biol. 2016 Jun 5;428(11):2488-2506. doi: 10.1016/j.jmb.2016.04.028. Epub 2016 Apr 30.).

Résumé | Liens | BibTeX

@article{RN1893,

title = {Functional and Structural Insights of the Zinc-Finger HIT protein family members Involved in Box C/D snoRNP Biogenesis},

author = {B. Bragantini and D. Tiotiu and B. Rothe and J. M. Saliou and H. Marty and S. Cianferani and B. Charpentier and M. Quinternet and X. Manival},

url = {https://www.ncbi.nlm.nih.gov/pubmed/27139642},

doi = {10.1016/j.jmb.2016.04.028},

issn = {1089-8638 (Electronic) 

0022-2836 (Linking)},

year  = {2016},

date = {2016-01-01},

journal = {J Mol Biol},

volume = {428},

number = {11},

pages = {2488-2506},

abstract = {Zf-HIT family members share the zf-HIT domain (ZHD), which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. Six proteins containing ZHD are present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes involved in gene regulation, chromatin remodeling, and snoRNP assembly. An interesting characteristic of the cellular complexes that ensure these functions is the presence of the RuvBL1/2/Rvb1/2 ATPases closely linked with zf-HIT proteins. Human ZNHIT6/BCD1 and its counterpart in yeast Bcd1p were previously characterized as assembly factors of the box C/D snoRNPs. Our data reveal that the ZHD of Bcd1p is necessary but not sufficient for yeast growth and that the motif has no direct RNA-binding capacity but helps Bcd1p maintain the box C/D snoRNAs level in steady state. However, we demonstrated that Bcd1p interacts nonspecifically with RNAs depending on their length. Interestingly, the ZHD of Bcd1p is functionally interchangeable with that of Hit1p, another box C/D snoRNP assembly factor belonging to the zf-HIT family. This prompted us to use NMR to solve the 3D structures of ZHD from yeast Bcd1p and Hit1p to highlight the structural similarity in the zf-HIT family. We identified structural features associated with the requirement of Hit1p and Bcd1p ZHD for cell growth and box C/D snoRNA stability under heat stress. Altogether, our data suggest an important role of ZHD could be to maintain functional folding to the rest of the protein, especially under heat stress conditions.},

note = {Bragantini, Benoit 

Tiotiu, Decebal 

Rothe, Benjamin 

Saliou, Jean-Michel 

Marty, Helene 

Cianferani, Sarah 

Charpentier, Bruno 

Quinternet, Marc 

Manival, Xavier 

eng 

Research Support, Non-U.S. Gov't 

Netherlands 

2016/05/04 06:00 

J Mol Biol. 2016 Jun 5;428(11):2488-2506. doi: 10.1016/j.jmb.2016.04.028. Epub 2016 Apr 30.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

Fermer

2015

Reginald, Kavita; Chaoui, Karima; Roncagalli, Romain; Beau, Mathilde; Menoita, Marisa Goncalves; Monsarrat, Bernard; Burlet-Schiltz, Odile; Malissen, M; Peredo, Anne Gonzalez; Malissen, Bernard

Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells Article de journal

Dans: The Journal of Immunology, vol. 195, no. 11, p. 5472–5481, 2015.