@article{RN1310,

title = {Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts},

author = {R Grzela and J Nusbaum and S Fieulaine and F Lavecchia and M Desmadril and N Nhiri and A Van Dorsselaer and S Cianférani and E Jacquet and T Meinnel and C Giglione},

doi = {10.1016/j.bbapap.2017.10.007},

year  = {2018},

date = {2018-02-01},

journal = {Biochim Biophys Acta.},

volume = {1866},

number = {2},

pages = {348-355},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{A2018,

title = {Asb2α-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development},

author = {Métais A and Lamsoul I and Melet A and Uttenweiler-Joseph S and Poincloux R and Stefanovic S and Valière A and Gonzalez Peredo A and Stella A and Burlet-Schiltz O and Zaffran S and Lutz PG and Moog-Lutz C},

doi = {10.1161/CIRCRESAHA.117.312015},

year  = {2018},

date = {2018-01-26},

journal = {Circ Res.},

volume = {122},

number = {6},

pages = {34-48},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN1308,

title = {Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains},

author = {M Mori and L Kovalenko and S Malancona and F Saladini and D De Forni and M Pires and N Humbert and E Real and T Botzanowski and S Cianférani and A Giannini and MC. Dasso Lang and G Cugia and B Poddesu and F Lori and M Zazzi and S Harper and V Summa and Y Mely and M Botta},

doi = {10.1021/acschembio.7b00907},

year  = {2018},

date = {2018-01-19},

journal = {ACS Chem Biol.},

volume = {13},

number = {1},

pages = {253-266},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN1306,

title = {Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development},

author = {G Husson and A Delangle and J O'Hara and S Cianférani and A Gervais and A Van Dorsselaer and D Bracewell and C Carapito},

doi = {10.1021/acs.analchem.7b03965},

year  = {2018},

date = {2018-01-16},

journal = {Anal Chem.},

volume = {90},

number = {2},

pages = {1241-1247},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{L2018,

title = {Metabolome and proteome changes between biofilm and planktonic phenotypes of the marine bacterium Pseudoalteromonas lipolytica TC8},

author = {Favre L and Ortalo-Magné A and Pichereaux C and Gargaros A and Burlet-Schiltz O and Cotelle V and Culioli G.},

doi = {10.1080/08927014.2017.1413551},

year  = {2018},

date = {2018-01-10},

journal = {Biofouling},

volume = {34},

number = {2},

pages = {132-148},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{rayapuram_quantitative_2018,

title = {Quantitative Phosphoproteomic Analysis Reveals Shared and Specific Targets ofArabidopsisMitogen-Activated Protein Kinases (MAPKs) MPK3, MPK4, and MPK6},

author = {Naganand Rayapuram and Jean Bigeard and Hanna Alhoraibi and Ludovic Bonhomme and Anne-Marie Hesse and Joëlle Vinh and Heribert Hirt and Delphine Pflieger},

doi = {10.1074/mcp.RA117.000135},

issn = {1535-9484},

year  = {2018},

date = {2018-01-01},

journal = {Molecular & cellular proteomics: MCP},

volume = {17},

number = {1},

pages = {61--80},

abstract = {In Arabidopsis, mitogen-activated protein kinases MPK3, MPK4, and MPK6 constitute essential relays for a variety of functions including cell division, development and innate immunity. Although some substrates of MPK3, MPK4 and MPK6 have been identified, the picture is still far from complete. To identify substrates of these MAPKs likely involved in cell division, growth and development we compared the phosphoproteomes of wild-type andmpk3,mpk4, andmpk6.To study the function of these MAPKs in innate immunity, we analyzed their phosphoproteomes following microbe-associated molecular pattern (MAMP) treatment. Partially overlapping substrates were retrieved for all three MAPKs, showing target specificity to one, two or all three MAPKs in different biological processes. More precisely, our results illustrate the fact that the entity to be defined as a specific or a shared substrate for MAPKs is not a phosphoprotein but a particular (S/T)P phosphorylation site in a given protein. One hundred fifty-two peptides were identified to be differentially phosphorylated in response to MAMP treatment and/or when compared between genotypes and 70 of them could be classified as putative MAPK targets. Biochemical analysis of a number of putative MAPK substrates by phosphorylation and interaction assays confirmed the global phosphoproteome approach. Our study also expands the set of MAPK substrates to involve other protein kinases, including calcium-dependent (CDPK) and sugar nonfermenting (SnRK) protein kinases.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{burger_gentle_2018,

title = {Gentle Introduction to the Statistical Foundations of False Discovery Rate in Quantitative Proteomics},

author = {Thomas Burger},

doi = {10.1021/acs.jproteome.7b00170},

issn = {1535-3907},

year  = {2018},

date = {2018-01-01},

journal = {Journal of Proteome Research},

volume = {17},

number = {1},

pages = {12--22},

abstract = {The vocabulary of theoretical statistics can be difficult to embrace from the viewpoint of computational proteomics research, even though the notions it conveys are essential to publication guidelines. For example, "adjusted p-values", "q-values", and "false discovery rates" are essentially similar concepts, whereas "false discovery rate" and "false discovery proportion" must not be confused, even though "rate" and "proportion" are related in everyday language. In the interdisciplinary context of proteomics, such subtleties may cause misunderstandings. This article aims to provide an easy-to-understand explanation of these four notions (and a few other related ones). Their statistical foundations are dealt with from a perspective that largely relies on intuition, addressing mainly protein quantification but also, to some extent, peptide identification. In addition, a clear distinction is made between concepts that define an individual property (i.e., related to a peptide or a protein) and those that define a set property (i.e., related to a list of peptides or proteins).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{el_kennani_proteomic_2018,

title = {Proteomic Analysis of Histone Variants and Their PTMs: Strategies and Pitfalls},

author = {Sara El Kennani and Marion Crespo and Jérôme Govin and Delphine Pflieger},

doi = {10.3390/proteomes6030029},

issn = {2227-7382},

year  = {2018},

date = {2018-01-01},

journal = {Proteomes},

volume = {6},

number = {3},

abstract = {Epigenetic modifications contribute to the determination of cell fate and differentiation. The molecular mechanisms underlying histone variants and post-translational modifications (PTMs) have been studied in the contexts of development, differentiation, and disease. Antibody-based assays have classically been used to target PTMs, but these approaches fail to reveal combinatorial patterns of modifications. In addition, some histone variants are so similar to canonical histones that antibodies have difficulty distinguishing between these isoforms. Mass spectrometry (MS) has progressively developed as a powerful technology for the study of histone variants and their PTMs. Indeed, MS analyses highlighted exquisitely complex combinations of PTMs, suggesting “crosstalk” between them, and also revealed that PTM patterns are often variant-specific. Even though the sensitivity and acquisition speed of MS instruments have considerably increased alongside the development of computational tools for the study of multiple PTMs, it remains challenging to correctly describe the landscape of histone PTMs, and in particular to confidently assign modifications to specific amino acids. Here, we provide an inventory of MS-based strategies and of the pitfalls inherent to histone PTM and variant characterization, while stressing the complex interplay between PTMs and histone sequence variations. We will particularly illustrate the roles played by MS-based analyses in identifying and quantifying histone variants and modifications.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{el_kennani_systematic_2018,

title = {Systematic quantitative analysis of Ħ2A and Ħ2B variants by targeted proteomics},

author = {Sara El Kennani and Annie Adrait and Olga Permiakova and Anne-Marie Hesse and Côme Ialy-Radio and Myriam Ferro and Virginie Brun and Julie Cocquet and Jérôme Govin and Delphine Pflieger},

doi = {10.1186/s13072-017-0172-y},

issn = {1756-8935},

year  = {2018},

date = {2018-01-01},

journal = {Epigenetics & Chromatin},

volume = {11},

number = {1},

pages = {2},

abstract = {BACKGROUND: Histones organize DNA into chromatin through a variety of processes. Among them, a vast diversity of histone variants can be incorporated into chromatin and finely modulate its organization and functionality. Classically, the study of histone variants has largely relied on antibody-based assays. However, antibodies have a limited efficiency to discriminate between highly similar histone variants. 

RESULTS: In this study, we established a mass spectrometry-based analysis to address this challenge. We developed a targeted proteomics method, using selected reaction monitoring or parallel reaction monitoring, to quantify a maximum number of histone variants in a single multiplexed assay, even when histones are present in a crude extract. This strategy was developed on H2A and H2B variants, using 55 peptides corresponding to 25 different histone sequences, among which a few differ by a single amino acid. The methodology was then applied to mouse testis extracts in which almost all histone variants are expressed. It confirmed the abundance profiles of several testis-specific histones during successive stages of spermatogenesis and the existence of predicted H2A.L.1 isoforms. This methodology was also used to explore the over-expression pattern of H2A.L.1 isoforms in a mouse model of male infertility. 

CONCLUSIONS: Our results demonstrate that targeted proteomics is a powerful method to quantify highly similar histone variants and isoforms. The developed method can be easily transposed to the study of human histone variants, whose abundance can be deregulated in various diseases.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{adam_phd_2018,

title = {The PHD finger protein Spp1 has distinct functions in the Set1 and the meiotic DSB formation complexes},

author = {Céline Adam and Raphaël Guérois and Anna Citarella and Laura Verardi and Florine Adolphe and Claire Béneut and Vérane Sommermeyer and Claire Ramus and Jérôme Govin and Yohann Couté and Valérie Borde},

doi = {10.1371/journal.pgen.1007223},

issn = {1553-7404},

year  = {2018},

date = {2018-01-01},

journal = {PLoS genetics},

volume = {14},

number = {2},

pages = {e1007223},

abstract = {Histone H3K4 methylation is a feature of meiotic recombination hotspots shared by many organisms including plants and mammals. Meiotic recombination is initiated by programmed double-strand break (DSB) formation that in budding yeast takes place in gene promoters and is promoted by histone H3K4 di/trimethylation. This histone modification is recognized by Spp1, a PHD finger containing protein that belongs to the conserved histone H3K4 methyltransferase Set1 complex. During meiosis, Spp1 binds H3K4me3 and interacts with a DSB protein, Mer2, to promote DSB formation close to gene promoters. How Set1 complex- and Mer2- related functions of Spp1 are connected is not clear. Here, combining genome-wide localization analyses, biochemical approaches and the use of separation of function mutants, we show that Spp1 is present within two distinct complexes in meiotic cells, the Set1 and the Mer2 complexes. Disrupting the Spp1-Set1 interaction mildly decreases H3K4me3 levels and does not affect meiotic recombination initiation. Conversely, the Spp1-Mer2 interaction is required for normal meiotic recombination initiation, but dispensable for Set1 complex-mediated histone H3K4 methylation. Finally, we provide evidence that Spp1 preserves normal H3K4me3 levels independently of the Set1 complex. We propose a model where Spp1 works in three ways to promote recombination initiation: first by depositing histone H3K4 methylation (Set1 complex), next by "reading" and protecting histone H3K4 methylation, and finally by making the link with the chromosome axis (Mer2-Spp1 complex). This work deciphers the precise roles of Spp1 in meiotic recombination and opens perspectives to study its functions in other organisms where H3K4me3 is also present at recombination hotspots.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{de_muyt_meiotic_2018,

title = {A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation},

author = {Arnaud De Muyt and Alexandra Pyatnitskaya and Jessica Andréani and Lepakshi Ranjha and Claire Ramus and Raphaëlle Laureau and Ambra Fernandez-Vega and Daniel Holoch and Elodie Girard and Jérome Govin and Raphaël Margueron and Yohann Couté and Petr Cejka and Raphaël Guérois and Valérie Borde},

doi = {10.1101/gad.308510.117},

issn = {1549-5477},

year  = {2018},

date = {2018-01-01},

journal = {Genes & Development},

volume = {32},

number = {3-4},

pages = {283--296},

abstract = {Meiotic crossover formation requires the stabilization of early recombination intermediates by a set of proteins and occurs within the environment of the chromosome axis, a structure important for the regulation of meiotic recombination events. The molecular mechanisms underlying and connecting crossover recombination and axis localization are elusive. Here, we identified the ZZS (Zip2-Zip4-Spo16) complex, required for crossover formation, which carries two distinct activities: one provided by Zip4, which acts as hub through physical interactions with components of the chromosome axis and the crossover machinery, and the other carried by Zip2 and Spo16, which preferentially bind branched DNA molecules in vitro. We found that Zip2 and Spo16 share structural similarities to the structure-specific XPF-ERCC1 nuclease, although it lacks endonuclease activity. The XPF domain of Zip2 is required for crossover formation, suggesting that, together with Spo16, it has a noncatalytic DNA recognition function. Our results suggest that the ZZS complex shepherds recombination intermediates toward crossovers as a dynamic structural module that connects recombination events to the chromosome axis. The identification of the ZZS complex improves our understanding of the various activities required for crossover implementation and is likely applicable to other organisms, including mammals.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{petosa_[new_2018,

title = {[A new hope to fight invasive fungal infection]},

author = {Carlo Petosa and Jérôme Govin and Flore Mietton},

doi = {10.1051/medsci/20183402007},

issn = {1958-5381},

year  = {2018},

date = {2018-01-01},

journal = {Medecine Sciences: M/S},

volume = {34},

number = {2},

pages = {123--125},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{garnaud_rim_2018,

title = {The Rim Pathway Mediates Antifungal Tolerance in Candida albicans through Newly Identified Rim101 Transcriptional Targets, Including Hsp90 and Ipt1},

author = {Cécile Garnaud and Encar García-Oliver and Yan Wang and Danièle Maubon and Sébastien Bailly and Quentin Despinasse and Morgane Champleboux and Jérôme Govin and Muriel Cornet},

doi = {10.1128/AAC.01785-17},

issn = {1098-6596},

year  = {2018},

date = {2018-01-01},

journal = {Antimicrobial Agents and Chemotherapy},

volume = {62},

number = {3},

abstract = {Invasive candidiasis (IC) is a major cause of morbidity and mortality despite antifungal treatment. Azoles and echinocandins are used as first-line therapies for IC. However, their efficacy is limited by yeast tolerance and the emergence of acquired resistance. Tolerance is a reversible stage created due to the yeast's capacity to counter antifungal drug exposure, leading to persistent growth. For Candida albicans, multiple stress signaling pathways have been shown to contribute to this adaptation. Among them, the pH-responsive Rim pathway, through its transcription factor Rim101p, was shown to mediate azole and echinocandin tolerance. The Rim pathway is fungus specific, is conserved among the members of the fungal kingdom, and plays a key role in pathogenesis and virulence. The present study aimed at confirming the role of Rim101p and investigating the implication of the other Rim proteins in antifungal tolerance in C. albicans, as well as the mechanisms underlying it. Time-kill curve experiments and colony formation tests showed that genetic inhibition of all the Rim factors enhances echinocandin and azole antifungal activity. Through RNA sequencing analysis of a rim101-/- mutant, a strain constitutively overexpressing RIM101, and control strains, we discovered novel Rim-dependent genes involved in tolerance, including HSP90, encoding a major molecular chaperone, and IPT1, involved in sphingolipid biosynthesis. Rim mutants were also hypersensitive to pharmacological inhibition of Hsp90. Taken together, these data suggest that Rim101 acts upstream of Hsp90 and that targeting the Rim pathway in combination with existing antifungal drugs may represent a promising antifungal strategy to indirectly but specifically target Hsp90 in yeasts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{he_characterization_2018,

title = {Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation},

author = {Huan He and Marie-Pierre Brenier-Pinchart and Laurence Braun and Alexandra Kraut and Bastien Touquet and Yohann Couté and Isabelle Tardieux and Mohamed-Ali Hakimi and Alexandre Bougdour},

doi = {10.7554/eLife.39887},

issn = {2050-084X},

year  = {2018},

date = {2018-01-01},

journal = {eLife},

volume = {7},

abstract = {The intracellular parasite Toxoplasma gondii, hijacks evolutionarily conserved host processes by delivering effector proteins into the host cell that shift gene expression in a timely fashion. We identified a parasite dense granule protein as GRA18 that once released in the host cell cytoplasm forms versatile complexes with regulatory elements of the β-catenin destruction complex. By interacting with GSK3/PP2A-B56, GRA18 drives β-catenin up-regulation and the downstream effects on host cell gene expression. In the context of macrophages infection, GRA18 induces the expression of a specific set of genes commonly associated with an anti-inflammatory response that includes those encoding chemokines CCL17 and CCL22. Overall, this study adds another original strategy by which T. gondii tachyzoites reshuffle the host cell interactome through a GSK3/β-catenin axis to selectively reprogram immune gene expression.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{picard_evolution_2018,

title = {Evolution of gene dosage on the Z-chromosome of schistosome parasites},

author = {Marion A L Picard and Celine Cosseau and Sabrina Ferré and Thomas Quack and Christoph G Grevelding and Yohann Couté and Beatriz Vicoso},

doi = {10.7554/eLife.35684},

issn = {2050-084X},

year  = {2018},

date = {2018-01-01},

journal = {eLife},

volume = {7},

abstract = {XY systems usually show chromosome-wide compensation of X-linked genes, while in many ZW systems, compensation is restricted to a minority of dosage-sensitive genes. Why such differences arose is still unclear. Here, we combine comparative genomics, transcriptomics and proteomics to obtain a complete overview of the evolution of gene dosage on the Z-chromosome of Schistosoma parasites. We compare the Z-chromosome gene content of African (Schistosoma mansoni and S. haematobium) and Asian (S. japonicum) schistosomes and describe lineage-specific evolutionary strata. We use these to assess gene expression evolution following sex-linkage. The resulting patterns suggest a reduction in expression of Z-linked genes in females, combined with upregulation of the Z in both sexes, in line with the first step of Ohno's classic model of dosage compensation evolution. Quantitative proteomics suggest that post-transcriptional mechanisms do not play a major role in balancing the expression of Z-linked genes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{legendre_diversity_2018,

title = {Diversity and evolution of the emerging Pandoraviridae family},

author = {Matthieu Legendre and Elisabeth Fabre and Olivier Poirot and Sandra Jeudy and Audrey Lartigue and Jean-Marie Alempic and Laure Beucher and Nadège Philippe and Lionel Bertaux and Eugène Christo-Foroux and Karine Labadie and Yohann Couté and Chantal Abergel and Jean-Michel Claverie},

doi = {10.1038/s41467-018-04698-4},

issn = {2041-1723},

year  = {2018},

date = {2018-01-01},

journal = {Nature Communications},

volume = {9},

number = {1},

pages = {2285},

abstract = {With DNA genomes reaching 2.5 Mb packed in particles of bacterium-like shape and dimension, the first two Acanthamoeba-infecting pandoraviruses remained up to now the most complex viruses since their discovery in 2013. Our isolation of three new strains from distant locations and environments is now used to perform the first comparative genomics analysis of the emerging worldwide-distributed Pandoraviridae family. Thorough annotation of the genomes combining transcriptomic, proteomic, and bioinformatic analyses reveals many non-coding transcripts and significantly reduces the former set of predicted protein-coding genes. Here we show that the pandoraviruses exhibit an open pan-genome, the enormous size of which is not adequately explained by gene duplications or horizontal transfers. As most of the strain-specific genes have no extant homolog and exhibit statistical features comparable to intergenic regions, we suggest that de novo gene creation could contribute to the evolution of the giant pandoravirus genomes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{eymard-vernain_poly-gamma-glutamate_2018,

title = {The poly-gamma-glutamate of Bacillus subtilis interacts specifically with silver nanoparticles},

author = {Elise Eymard-Vernain and Yohann Couté and Annie Adrait and Thierry Rabilloud and Géraldine Sarret and Cécile Lelong},

doi = {10.1371/journal.pone.0197501},

issn = {1932-6203},

year  = {2018},

date = {2018-01-01},

journal = {PloS One},

volume = {13},

number = {5},

pages = {e0197501},

abstract = {For many years, silver nanoparticles, as with other antibacterial nanoparticles, have been extensively used in manufactured products. However, their fate in the environment is unclear and raises questions. We studied the fate of silver nanoparticles in the presence of bacteria under growth conditions that are similar to those found naturally in the environment (that is, bacteria in a stationary phase with low nutrient concentrations). We demonstrated that the viability and the metabolism of a gram-positive bacteria, Bacillus subtilis, exposed during the stationary phase is unaffected by 1 mg/L of silver nanoparticles. These results can be partly explained by a physical interaction of the poly-gamma-glutamate (PGA) secreted by Bacillus subtilis with the silver nanoparticles. The coating of the silver nanoparticles by the secreted PGA likely results in a loss of the bioavailability of nanoparticles and, consequently, a decrease of their biocidal effect.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{abulfaraj_arabidopsis_2018,

title = {The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity},

author = {Aala A Abulfaraj and Kiruthiga Mariappan and Jean Bigeard and Prabhu Manickam and Ikram Blilou and Xiujie Guo and Salim Al-Babili and Delphine Pflieger and Heribert Hirt and Naganand Rayapuram},

doi = {10.26508/lsa.201800046},

issn = {2575-1077},

year  = {2018},

date = {2018-01-01},

journal = {Life Science Alliance},

volume = {1},

number = {2},

pages = {e201800046},

abstract = {Mammalian Ras-GTPase-activating protein SH3-domain-binding proteins (G3BPs) are a highly conserved family of RNA-binding proteins that link kinase receptor-mediated signaling to RNA metabolism. Mammalian G3BP1 is a multifunctional protein that functions in viral immunity. Here, we show that the Arabidopsis thaliana homolog of human G3BP1 negatively regulates plant immunity. Arabidopsis g3bp1 mutants showed enhanced resistance to the virulent bacterial pathogen Pseudomonas syringae pv. tomato. Pathogen resistance was mediated in Atg3bp1 mutants by altered stomatal and apoplastic immunity. Atg3bp1 mutants restricted pathogen entry into stomates showing insensitivity to bacterial coronatine-mediated stomatal reopening. AtG3BP1 was identified as a negative regulator of defense responses, which correlated with moderate up-regulation of salicylic acid biosynthesis and signaling without growth penalty.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{sage_single-particle_2018,

title = {Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators},

author = {Eric Sage and Marc Sansa and Shawn Fostner and Martial Defoort and Marc Gély and Akshay K Naik and Robert Morel and Laurent Duraffourg and Michael L Roukes and Thomas Alava and Guillaume Jourdan and Eric Colinet and Christophe Masselon and Ariel Brenac and Sébastien Hentz},

doi = {10.1038/s41467-018-05783-4},

issn = {2041-1723},

year  = {2018},

date = {2018-01-01},

journal = {Nature Communications},

volume = {9},

number = {1},

pages = {3283},

abstract = {One of the main challenges to overcome to perform nanomechanical mass spectrometry analysis in a practical time frame stems from the size mismatch between the analyte beam and the small nanomechanical detector area. We report here the demonstration of mass spectrometry with arrays of 20 multiplexed nanomechanical resonators; each resonator is designed with a distinct resonance frequency which becomes its individual address. Mass spectra of metallic aggregates in the MDa range are acquired with more than one order of magnitude improvement in analysis time compared to individual resonators. A 20 NEMS array is probed in 150 ms with the same mass limit of detection as a single resonator. Spectra acquired with a conventional time-of-flight mass spectrometer in the same system show excellent agreement. We also demonstrate how mass spectrometry imaging at the single-particle level becomes possible by mapping a 4-cm-particle beam in the MDa range and above.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{621,

title = {Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex.},

author = {A Berthier and M Vinod and G Porez and A Steenackers and J Alexandre and N Yamakawa and C Gheeraert and M Ploton and X Maréchal and J Dubois-Chevalier and A Hovasse and C Schaeffer-Reiss and S Cianférani and C Rolando and F Bray and H Duez and J Eeckhoute and T Lefebvre and B Staels and P Lefebvre},

doi = {10.1073/pnas.1805397115},

year  = {2018},

date = {2018-01-01},

journal = {Proc Natl Acad Sci U S A.},

volume = {15},

number = {47},

pages = {E11033-E11042.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{606,

title = {N-terminome and proteogenomic analysis of the Methylobacterium extorquens DM4 reference strain for dichloromethane utilization.},

author = {S Bibi-Triki and G Husson and B Maucourt and S Vuilleumier and C Carapito and F Bringel},

year  = {2018},

date = {2018-01-01},

journal = {J Proteomics.},

number = {179},

pages = {131-139},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{626,

title = {Dissociating effect of salivary gland extract from Ixodes ricinus on human fibroblasts: Potential impact on Borrelia transmission.},

author = {A Boeuf and G Schnell and Q Bernard and A Kern and B Westermann and L Ehret-Sabatier and A Grillon and F Schramm and B Jaulhac and N Boulanger},

year  = {2018},

date = {2018-01-01},

journal = {Ticks Tick Borne Dis.},

volume = {pii: S1877-959X(18)30014-1.},

note = {2012/29},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{616,

title = {Multi-OMICS analyses unveil STAT1 as a potential modifier gene in mevalonate kinase deficiency.},

author = {R Carapito and C Carapito and A Morlon and N Paul and AS. Vaca Jacome and G Alsaleh and V Rolli and O Tahar and I Aouadi and M Rompais and F Delalande and A Pichot and P Georgel and L Messer and J Sibilia and S Cianferani and A Van Dorsselaer and S Bahram},

year  = {2018},

date = {2018-01-01},

journal = {Ann Rheum Dis.},

volume = {77},

number = {11},

pages = {1675-1687.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{605,

title = {Cleavable Binary Dyads: Simplifying Data Extraction and Increasing Storage Density in Digital Polymers.},

author = {G Cavallo and S Poyer and JA. Amalian and F Dufour and A Burel and C Carapito and L Charles and JF. Lutz},

year  = {2018},

date = {2018-01-01},

journal = {Angew Chem Int Ed Engl.},

volume = {57},

number = {21},

pages = {6266-6269.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{597,

title = {Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells},

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