ProFI Proteomics
The Proteomics French Infrastructure is a national project set up to provide a unified service platform in proteomics studies.
It's open to both public and private collaborations.
Proteomics Services
Large scale protein identification and quantification
Current proteomics methods and instrumentation represent today a powerful tool to get new insights into complex biological systems.
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Targeted quantification
Targeted strategies have emerged ten years ago and are best suited when precise, ideally absolute, quantification of finite sets of proteins are required with highest sensitivity.
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Post-translational modifications: detection and quantification
Proteins are very often the subject of various post-translational modifications (PTMs) that can impact their association with other proteins and globally other biomolecules, their subcellular localization and their stability.
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Interactomics and protein complexes
Interactomics and protein complexes investigations are also based on our strategies and instrumentation for large-scale and targeted quantification.
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Characterization of intact proteins and complexes
The next frontiers in proteome research are the study of protein-ligand interactions, protein-peptide and protein-protein complexes, together with entire protein interaction networks by high-throughput methods.
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How to submit a request
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ProFI Proteomics Skills
Publications
On the international stage
National Networks
Tools and methods for the community
Last News
Inserm Workshop 262: Mass Spectrometry for Structural Biology
This workshop will present the fundamental and applied aspects of Mass Spectrometry-based structural techniques, as well as data analysis procedures. State-of-the-art lectures will be given by experts in the field, destined to both non-MS and MS specialists. It will...
ProteoRE, a web application for the discovery of biomarkers of diagnostic interest
Although biomarkers are widely used, important limitations have been identified due to their lack of specificity. An a priori knowledge-based approach (i.e. based on mechanistic criteria specific to the genesis of a disease) that takes advantage of ever-increasing “omics” databases could be a powerful way to identify biomarkers, provided that scientists have access to computer tools to search the data even when they have little experience in programming or bioinformatics support.
HDX-Viewer: interactive 3D visualization of hydrogen-deuterium exchange data
Bouyssié D, Lesne J, Locard-Paulet M, Albigot R, Burlet-Schiltz O, Marcoux J. Bioinformatics. 2019 Jul 9. pii: btz550. doi: 10.1093/bioinformatics/btz550. With the advent of fully automated sample preparation robots for Hydrogen–Deuterium eXchange coupled to Mass...
