ProFI Proteomics
The Proteomics French Infrastructure is a national project set up to provide a unified service platform in proteomics studies.
It's open to both public and private collaborations.
Proteomics Services
Large scale protein identification and quantification
Current proteomics methods and instrumentation represent today a powerful tool to get new insights into complex biological systems.
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Targeted quantification
Targeted strategies have emerged ten years ago and are best suited when precise, ideally absolute, quantification of finite sets of proteins are required with highest sensitivity.
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Post-translational modifications: detection and quantification
Proteins are very often the subject of various post-translational modifications (PTMs) that can impact their association with other proteins and globally other biomolecules, their subcellular localization and their stability.
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Interactomics and protein complexes
Interactomics and protein complexes investigations are also based on our strategies and instrumentation for large-scale and targeted quantification.
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Characterization of intact proteins and complexes
The next frontiers in proteome research are the study of protein-ligand interactions, protein-peptide and protein-protein complexes, together with entire protein interaction networks by high-throughput methods.
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How to submit a request
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ProFI Proteomics Skills
Publications
On the international stage
National Networks
Tools and methods for the community
Last News
35th congress of the French Proteomics society
ProFI supports the 35th congress of the French Proteomics society, SFEAP 2018, which is organized by the Toulouse site of ProFI and the “Pole Protéomique” of Montpellier.
Mass spectrometry analysis of IL-33 proteolytic maturation
IL-33 is a mediator of allergic inflammation and is localized in mucosal tissues to respond rapidly to environmental insults. These include allergens themselves, which can directly activate IL-33 through their intrinsic proteolytic activity. We used mass spectrometry to characterize maturation processes induced by allergens, involved in activation of IL-33 and asthma.
N-terminal oriented proteomics approach
Mass-spectrometry based proteomics combined with N-terminal chemical labelling using TMPP allows the characterization of proteolytic cleavage sites of Persephone by microbial proteases
