ProFi Proteomics
  • Home
  • About Us
  • News
  • Publications
  • Activities
    • Proteomics Services
    • How to Submit a Request
    • National Networks
    • On the International Stage
    • Tools and Methods for the Community
  • Training
  • Proline
    • Summary
    • Proline Features
    • Proline Downloads
    • Proline Support
    • Archives – Previous Versions
    • Other Tools
    • Forum
15/02/2022 par Véronique Dupierris
Major publication

ProMetIS: open data and bioinformatics workflows for multi-omics phenotyping of cohorts

ProMetIS: open data and bioinformatics workflows for multi-omics phenotyping of cohorts
15/02/2022 par Véronique Dupierris
Major publication

The integration of multi-omics data is a major approach for the understanding of pathophysiological mechanisms and the discovery of biomarkers in health. However, few multi-omics data are publicly available to date.

In a study recently published in the open data reference journal Scientific Data1, the four French Infrastructures (INBS) in Mouse Phenogenomics (Phenomin-ICS; www.phenomin.fr), Proteomics (ProFI; www.profiproteomics.fr), Metabolomics and Fluxomics (MetaboHUB; www.metabohub.fr) and Bioinformatics (IFB; www.france-bioinformatique.fr) have joined forces to develop and make available the data and processing pipeline for the characterization of murine samples by combined proteomics and metabolomics approaches.

Nine raw datasets (1 preclinical, 2 proteomic and 6 metabolomic), corresponding to the study of the knock-out mice for the Lat (linker for activation of T cells) and Mx2 genes (MX dynamin-like GTPase 2), are available in the reference repositories (IMPC, PRIDE, and MetaboLights). In addition, the pre-processed data and the bioinformatics analysis pipeline are also available as an open access R package (github.com/IFB-ElixirFr/ProMetIS).

The ProMetIS pilot study thus represents a significant advance towards molecular phenotyping of cohorts. In particular, the data provide unique information on the functional characterization of the Lat and Mx2 genes. They will also become a reference for accessibility, reproducibility and interoperability (FAIR criteria) in the field of multi-omics studies. These data will be particularly valuable for developing new approaches for bioinformatic and biostatistic integration.

 

1Imbert, A., Rompais, M., Selloum, M., Castelli, F., Mouton-Barbosa, E., Brandolini-Bunlon, M., Chu-Van, E., Joly, C., Hirschler, A., Roger, P., Burger, T., Leblanc, S., Sorg, T., Ouzia, S., Vandenbrouck, Y., Médigue, C., Junot, C., Ferro, M., Pujos-Guillot, E., de Peredo, A. G., Fenaille, F., Carapito, C., Herault, Y., & Thévenot, E. A. (2021). ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis. Scientific Data, 8(1). https://doi.org/10.1038/s41597-021-01095-3

Article précédentThematic course “Quantitative proteomics” 2022Article suivant ProlineSuite Version 2.2.0 : New Version to improve the PTMs oriented functionalities

About The Blog

Nulla laoreet vestibulum turpis non finibus. Proin interdum a tortor sit amet mollis. Maecenas sollicitudin accumsan enim, ut aliquet risus.

Articles récents

timsTOF SCP mass spectrometer installed at ProteoToul13/04/2023
Online CIU of therapeutic mAB Glyco-Variants through Direct Hyphenation of CEX with Native Ion Mobility–MS23/03/2023
ProlineSuite Version 2.2.0 : New Version to improve the PTMs oriented functionalities07/02/2023

Catégories

  • Equipment
  • Events
  • Major publication
  • Permanent training
  • Publication
  • Software
  • Training
  • Workshop

Méta

  • Connexion
  • Flux des publications
  • Flux des commentaires
  • Site de WordPress-FR

Categories

  • Equipment (1)
  • Events (5)
  • Major publication (13)
  • Permanent training (1)
  • Publication (5)
  • Software (8)
  • Training (9)
  • Workshop (5)

Recent Posts

timsTOF SCP mass spectrometer installed at ProteoToul13/04/2023
Online CIU of therapeutic mAB Glyco-Variants through Direct Hyphenation of CEX with Native Ion Mobility–MS23/03/2023
ProlineSuite Version 2.2.0 : New Version to improve the PTMs oriented functionalities07/02/2023

Why ProFI?

The Proteomics French Infrastructure is a national project set up to provide a unified service platform in proteomics studies. It’s open to both public and private collaborations.

© 2023 ProFI - v2302 -Credits & legal notice

Recent Posts

timsTOF SCP mass spectrometer installed at ProteoToul13/04/2023
Online CIU of therapeutic mAB Glyco-Variants through Direct Hyphenation of CEX with Native Ion Mobility–MS23/03/2023
ProlineSuite Version 2.2.0 : New Version to improve the PTMs oriented functionalities07/02/2023
ProMetIS: open data and bioinformatics workflows for multi-omics phenotyping of cohorts15/02/2022
Thematic course “Quantitative proteomics” 202215/02/2022

Categories

  • Equipment (1)
  • Events (5)
  • Major publication (13)
  • Permanent training (1)
  • Publication (5)
  • Software (8)
  • Training (9)
  • Workshop (5)

We are using cookies to give you the best experience on our website.

You can find out more about which cookies we are using or switch them off and read our privacy statement. .

ProFi Proteomics
Powered by  GDPR Cookie Compliance
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.

By clicking on "Accept", you accept the use of cookies from this site and our privacy statement.

You can adjust all of your cookie settings by navigating the tabs on the left hand side.

Strictly Necessary Cookies

Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.

If you disable this cookie, we will not be able to save your preferences. This means that every time you visit this website you will need to enable or disable cookies again.

Privacy Statement

By clicking on "Accept", you accept the use of cookies from this site and our privacy statement.