New datastore architecture, separation of Instrument and Fractionnation rules, add new export formats, enhancement of PTM Sites managment and label-free quantitation, …

Get new version: Proline Zero V2.0 Windows x64


Warning: If you are doing an upgrade from previous version, be aware that  an important Proline database upgrade is needed. It is highly recommended to make a copy of your databases before the upgrade process (see ProlineSuite Installation Guide).

Release Note

  • New feature in Proline Server:
    • Change managment on Instrument and Fractionnation Rules : now separated
      • Fragmentation rules can be specified when running “Generate Spectrum Matches”
      • Fragmentation rules set should be specified at import
      • Fragmentation rules set can be configured
    •  Export
      • Spectra librairies could be exported into spectronaut or peakview format.
      • mzIdentML export format is now supported
    • LC-MS quantitation
      • Change the parameter managment
      • Some enhancement
        • Be more tolerant to LC-MS alignment outliers
        • log warn if landmarks cannot be smoothed
        • Feature mapping method “PEPTIDE_IDENTITY” now takes into account clusterized features
    • Label Free quantitation
      •  allow quantifier based on quantitative data read from third party software : MaxQuant results
    • Bug Fixes
      • Quantitation : error getting run for quantitation datasets. That was causing wrong assignments in cross assignment within group quantitation algorithm
      • Retrieve Sequence error : When cloning Identification Summary, clone also MSI Search (needed in case of quanti on leaf)
      • Import Mascot with invalid ptm classifier
      • Properties error for Search Result created with separated Decoy mode.
  • New feature in Proline Proline Admin
    • User managment modified. Allowed operation: create, activate, disable, change password.
    • Project managment modified. Allowed operation: create, activate, disable, archive, restore.
    • Database managment: initialize, check for update, update ….
  • New feature in Proline Studio
    • Graphical
      • Changed PTM Site view
      • Add Information in some display (protein description in quantitation view, …)
      • Copy/Paste of html cell supported for “search” or “filter” in display
      • Show the Merge Mode used when creating merged dataset: union or aggregation
      • PTM display on peptide sequences was missing in some views
      • drag’n’drop from All imported panel takes filters into account fixes
      • Bug fix on filters mapping for join
      • Fixes som bugs in Venn diagram graphics
    • Algorithm
      • Import duration bug (wrong value was displayed)
      • Add validation filter on #C13 (isotope offset)
      • Fix bug in validation with propagate: dataset tree wasn’t refreshed
      • Allow Generate Spectrum Matches even if already defined
    • Admin
      • Fragmentation rules set can be configured in Admin view
      • New view in admin dialog : list of projects/Databases/Databases Size with possibility to filter and export
      • None admin user can see admin info (not modify !)
    •  MzScope
      • a spectrum can now be made ‘persistent’ in the display to be visually compared with current spectrum
      • bug in mzdb QC metrics calculation corrected
      • Display options enhanced
      • Set min/max RT for extracted chromatograms to run duration
      • Bug fix for batch extraction
      • import any CSV file for batch extraction
      • enhanced zoom synchronization
    • LC-MS Quantitation
      • Map aligment display problem fixed
      • show reference dataset in experimental design
  • New feature in Proline Zero
    •  Enhanced launcher, now compatible with Windows and Linux