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09/03/2020 par Véronique Dupierris
Major publication, Software

Proline: an efficient and user-friendly software suite for large-scale proteomics

Proline: an efficient and user-friendly software suite for large-scale proteomics
09/03/2020 par Véronique Dupierris
Major publication, Software
We are pleased and very proud to announce the publication of Proline in Bioinformatics.
Motivation

The proteomics field requires the production and publication of reliable mass spectrometry-based identification and quantification results. Although many tools or algorithms exist, very few consider the importance of combining, in a unique software environment, efficient processing algorithms and a data management system to process and curate hundreds of datasets associated with a single proteomics study.

 

Results

Here, we present Proline, a robust software suite for analysis of MS-based proteomics data which collects, processes, allows visualization and publication of proteomics datasets. We illustrate its ease of use for various steps in the validation and quantification workflow, its data curation capabilities and its computational efficiency. The DDA label-free quantification workflow efficiency was assessed by comparing results obtained with Proline to those obtained with a widely used software using a spiked-in sample. This assessment demonstrated Proline’s ability to provide high quantification accuracy in a user-friendly interface for datasets of any size.

 

Availability

Proline is available for Windows and Linux under CECILL open-source license. It can be deployed in client-server mode or in standalone mode at http://proline.profiproteomics.fr/#downloads.

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Recent Posts

Welcome to ProFI’s new nodes !02/11/2023
timsTOF SCP mass spectrometer installed at ProteoToul13/04/2023
Online CIU of therapeutic mAB Glyco-Variants through Direct Hyphenation of CEX with Native Ion Mobility–MS23/03/2023

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Recent Posts

Welcome to ProFI’s new nodes !02/11/2023
timsTOF SCP mass spectrometer installed at ProteoToul13/04/2023
Online CIU of therapeutic mAB Glyco-Variants through Direct Hyphenation of CEX with Native Ion Mobility–MS23/03/2023
ProlineSuite Version 2.2.0 : New Version to improve the PTMs oriented functionalities07/02/2023
ProMetIS: open data and bioinformatics workflows for multi-omics phenotyping of cohorts15/02/2022

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